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醫(yī)藥級(jí)碳酸鎂:抗酸作用的科學(xué)機(jī)制

點(diǎn)擊數(shù):1112025-08-18 17:42:29 來(lái)源: 氧化鎂|碳酸鎂|輕質(zhì)氧化鎂|河北鎂神科技股份有限公司

新聞?wù)?醫(yī)藥級(jí)碳酸鎂作為抗酸劑,其核心功能是“中和胃內(nèi)過(guò)量胃酸(主要成分為鹽酸HCl)”,緩解胃酸過(guò)多引發(fā)的胃痛、胃灼熱(燒心)、反酸等癥狀,背后是明確的酸堿中和反應(yīng)與生理調(diào)節(jié)作用。

  抗酸作用的科學(xué)機(jī)制:快速中和胃酸,緩解“胃灼熱”的化學(xué)邏輯


  醫(yī)藥級(jí)碳酸鎂作為抗酸劑,其核心功能是“中和胃內(nèi)過(guò)量胃酸(主要成分為鹽酸HCl)”,緩解胃酸過(guò)多引發(fā)的胃痛、胃灼熱(燒心)、反酸等癥狀,背后是明確的酸堿中和反應(yīng)與生理調(diào)節(jié)作用。

  1.核心化學(xué)反應(yīng):高效中和胃酸,降低胃內(nèi)pH值

  胃內(nèi)正常pH值為0.9~1.5(空腹時(shí)),當(dāng)胃酸分泌過(guò)多(如胃炎、胃潰瘍患者),pH值會(huì)進(jìn)一步降低,刺激胃黏膜引發(fā)疼痛。碳酸鎂進(jìn)入胃后,會(huì)與鹽酸發(fā)生快速中和反應(yīng):

  MgCO?+2HCl→MgCl?+H?O+CO?↑

  反應(yīng)特點(diǎn):1mol碳酸鎂可中和2mol鹽酸,中和能力強(qiáng)(優(yōu)于氫氧化鋁,后者1mol僅中和3mol鹽酸,但起效slower);且反應(yīng)速率快,通常服用后10~15分鐘即可緩解燒心癥狀(普通抗酸劑如碳酸鈣起效需20~30分鐘)。

  產(chǎn)物安全性:反應(yīng)生成的氯化鎂(MgCl?)可溶于水,部分被腸道吸收(鎂元素為人體必需礦物質(zhì),可補(bǔ)充每日所需的10%~15%),未吸收部分隨糞便排出,無(wú)殘留毒性;生成的二氧化碳(CO?)量較少,僅少數(shù)人可能出現(xiàn)輕微腹脹(遠(yuǎn)低于碳酸鈣的產(chǎn)氣效應(yīng))。

  2.附加保護(hù)作用:間接修復(fù)胃黏膜屏障

  除直接中和胃酸外,碳酸鎂還能通過(guò)兩個(gè)途徑保護(hù)胃黏膜:

  提高胃內(nèi)pH值:中和胃酸后,胃內(nèi)pH值可從0.9~1.5升至3.0~5.0,這個(gè)pH范圍可抑制“胃蛋白酶”的活性(胃蛋白酶是胃內(nèi)主要的消化酶,在pH<2時(shí)活性最強(qiáng),會(huì)加劇胃黏膜損傷),減少酶對(duì)受損黏膜的進(jìn)一步破壞;

  形成弱保護(hù)膜:部分未完全溶解的碳酸鎂顆粒會(huì)附著在胃黏膜表面(尤其是潰瘍創(chuàng)面),形成一層薄薄的物理屏障,阻隔胃酸、胃蛋白酶與黏膜的直接接觸,為黏膜修復(fù)爭(zhēng)取時(shí)間。

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